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Neural Network Development Group

Our goal is to understand the mechanisms that underlie the development of neural circuits and the emergence of coordinated function. We use the embryonic nervous system of Drosophila as a model, focussing on the development of the motor network that generates the simple crawling movements of the Drosophila larva.

Drosophila has been extremely influential for our understanding of mechanisms of neurogenesis and axon guidance, which have been highly conserved from flies to humans. Drosophila brings three crucial strengths to this kind of analysis. The first is that we can work with identified neurons to which we can return again and again, as they develop and in experiments. The second is that by using targeted genetic constructs we can access specific cells in the developing network for experimentation and analysis (Diegelmann 2008). This is particularly important in the context of emerging function because it gives us an unparalleled ability to manipulate the excitability and synaptic connections of individual cells or cell classes. The third point is that we can use genetic methods to identify the molecular mechanisms that regulate structure, excitability and connectivity in the final stages of circuit assembly.

More recently, in collaboration with Sean Sweeney at the University of York, we have begun exploring how oxidative stress, a hallmark of a ageing and neurodegenerative conditions, affects synaptic terminal growth.

 

All Academic and Research Staff

Professor Michael Bate, FRS
Emeritus Professor of Developmental Neurobiology
Dr Jimena Berni
Research Fellow
Dr Louise Couton
Research associate
Dr Holly Ironfield
Postdoc (Wellcome Trust project grant)
Dr Matthias Landgraf
PI (Lecturer)
Dr Matthew Oswald
Postdoc (BBSRC project grant)

Positions

Our research is supported by a variety of funding agencies, including The Royal Society, The Wellcome Trust, the BBSRC, The Gates Cambridge Trust, The Katsia Foundation, Fondation Fyssen, and a Henslow Research Fellowship.

If you are interested in joining our group, please e-mail Michael Bate or Matthias Landgraf to discuss research projects and positions/lab space. We have been successful in obtaining support for promising scientists and are happy to help.

Collaborators

Richard Baines (Faculty of Life Sciences, University of Manchester)

Raymond Budjoso (Department of Veterinary Medicine, University of Cambridge)

Albert Cardona (HHMI Janelia Farm Research Campus)

Jan Felix Evers (Centre for Organismal Studies Heidelberg, Ruprecht-Karls- Universität, 69120 Heidelberg, Germany)

Lee Fradkin (Department of Molecular Cell Biology, Leiden University Medical Center)

Don van Meyel (Centre for Research in Neuroscience, McGill University)

Steve Stowers (Montana State University)

Sean Sweeney (Department of Zoology, University of York)

Gerd Technau (Institut für Genetik, Johannes Gutenberg Universität Mainz)

Davie van Vactor (Department of Cell Biology, Harvard Medical School)

Benjamin White (National Institute of Mental Health, NIH)

Marta Zlatic (HHMI Janelia Farm Research Campus)