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Dr Brian McCabe

Dr Brian McCabe

University Lecturer (retired)

Sub-Department of Animal Behaviour, Madingley
Office Phone: 01223 (7)41801

Biography:

After completing a PhD in neurophysiology, on mechanisms of induction of long-term changes in neuronal activity in the mammalian cerebral cortex, I held postdoctoral posts at Cambridge and Bristol Medical School, before becoming Senior Assistant in Research, Assistant Director of Research and University Lecturer in the Department of Zoology at Cambridge. Most of my career has been spent analysing neural mechanisms of learning and memory associated with filial imprinting in the chick, using behavioural, physiological, histological and biochemical techniques. For the last three years I have been Director of the Sub-Department of Animal Behaviour at Madingley.

Research Themes

Neurobiology, Biomechanics and Behaviour:
All Principal Investigators:

Neural mechanisms of learning and memory

Research Interests

The neural mechanisms of learning and memory, particularly imprinting in the domestic chick. The young of many species, when exposed to a conspicuous object (an imprinting stimulus), rapidly learn the object's characteristics and subsequently narrow their social preferences to it. This learning process is called imprinting, the study of which has yielded important insights into the nature of learning and memory. A part of the chick forebrain (the IMM) has been identified that is critical for imprinting. The available evidence indicates that the IMM is a site of memory for features of the imprinting stimulus. Currently, learning-specific changes in the IMM are being studied using behavioural analysis, electrophysiology, immunocytochemistry and molecular biology.

Key Publications

McCabe BJ (2013) Imprinting. WIREs Cogn Sci doi: 10.102/wcs.1231

Solomonia RO, Meparishvili M, Mikautadze E, Kunelauri N, Apkhazava D & McCabe BJ (2013). AMPA receptor phosphorylation and recognition memory: learning-related, time-dependent changes in the chick brain following filial imprinting. Exp Brain Research 226: 297-308 doi: 10.1007/s00221-013-3435-2

Town SM & McCabe BJ (2011). Neuronal Plasticity and Multisensory Integration in Filial Imprinting. PLoS ONE 6, e17777 doi: 10.1371/journal.pone.0017777.

Solomonia RO, Kunelauri N, Mikautadze E, Apkhazava D, McCabe BJ & Horn G (2011) Mitochondrial proteins, learning and memory: biochemical specialization of a memory system. Neuroscience, 194: 112-123

Suge R, Kato H & McCabe BJ (2010) Rapid induction of the immediate early gene c-fos in a chick forebrain system involved in memory. Exp Brain Res, 200:183-188

Jackson C, McCabe BJ, Nicol AU, Grout AS , Brown MW, Horn G (2008) Dynamics of a memory trace: effects of sleep on consolidation. Curr Biol, 18: 393-400 [see alsoStickgold R (2008) Sleep: the ebb and flow of memory consolidation. Curr Biol, 18: R423-R425]

Solomonia RO, Apkhazava D, Nozadze M, Jackson AP, McCabe BJ & Horn G (2008) Different forms of MARCKS protein are involved in memory formation in the learning process of imprinting. Exp Brain Res, 188: 323-330

Solomonia RO, Kotorashvili A, Kiguradze T, McCabe BJ, Horn G (2005) Ca2+/calmodulin protein kinase II and memory: learning-related changes in a localized region of the domestic chick brain. J Physiol (London), 569:643-653

Meredith RM, McCabe BJ, Kendrick KM, Horn G (2004) Amino acid neurotransmitter release and learning: a study of visual imprinting. Neuroscience, 126:249-256

Suge R, McCabe BJ (2004) Early stages of memory formation in filial imprinting: Fos-like immunoreactivity and behavior in the domestic chick. Neuroscience, 123:847-856

Solomonia RO, Morgan K, Kotorashvili A, McCabe BJ, Jackson AP, Horn G (2003) Analysis of differential gene expression supports a role for amyloid precursor protein and a protein kinase C substrate (MARCKS) in long-term memory. Eur J Neurosci, 17:1073-1081

McCabe BJ, Kendrick KM, Horn G (2001) Gamma-aminobutyric acid, taurine and learning: release of amino acids from slices of chick brain following filial imprinting.Neuroscience, 105:317-324

Other Publications