Research in Zoology
This group aims to dissect the cellular and molecular networks that regulate animal biology. It focuses on fundamental research in two areas. The first is the mechanisms that regulate cell proliferation and the function of the nucleus. The second is intra- and intercellular signalling. We use a wide range of techniques including molecular, biochemical and genetic approaches, in vivo imaging and the analysis of whole animal function and behaviour. Howard Baylis investigates how intracellular signalling regulates the development and physiology of C. elegans. Cath Green studies how DNA replication is temporally and spatially controlled by protein-protein interactions at replication forks. Torsten Krude investigates the replication of chromosomal DNA and its control in proliferating mammalian cells, focusing on the functional roles of non-coding Y RNAs in this process. Ron Laskey investigates the control of human DNA replication and explores the use of regulatory proteins as markers for cancer diagnosis. Birgitta Olofsson uses C. elegans to investigate how animals evaluate food and how they use this information to modify feeding behaviour. Jonathan Pines studies how cells initiate mitosis, and how they co-ordinate mitosis by ubiquitin-mediated proteolysis. Philip Zegerman's lab is interested in how the strict regulation of DNA replication is achieved during the cell cycle and when replication forks stall.