Animal Physiology
Simon Maddrell
Emeritus Honorary Professor
Email: shpm100@cam.ac.uk
Tel.: +44 (0)1223 334433
Control of insect organ systems by synergistic action of multiple hormones.
Detailed analysis of fluid secretion and its control in Malpighian tubules of Drosophila, where the use of mutants allows a deeper dissection of the system. This involves both extracellularly acting hormones and intracellular second messengers.
Co-ordination of fluid and ion transport by different epithelial cells involved in a single physiological process.
Mechanism of fluid transport by epithelia.
The light that comparative physiology may cast on the different ecological success of different animal groupings in stressful environments.
The effects of elevated and depressed concentrations of oxygen on the growth and size of animals.
Selected publications
- Maddrell, S.H.P. (1998). Why are there no insects in the open sea? Journal of Experimental Biology 201 , 2461-2464.
- Skaer, N.J.V., Nässel, D.R., Maddrell, S.H.P. & Tublitz, N.J. (2002). Neurochemical fine tuning of a peripheral tissue: peptidergic and aminergic regulation of fluid secretion by Malpighian in the tobacco hawkmoth M. sexta . J. exp. Biol. 205 , 1869-1880.
- O'Donnell, M.J., Dow, J.A.T., Huesmann, G.R., Tublitz, N.J. and Maddrell, S.H.P. (1996). Separate control of anion and cation transport in Malpighian tubules of Drosophila melanogaster . Journal of Experimental Biology 199 , 1163-1175.
- Denholm, B., Sudarsan, V., Pasalodos Sanchez, S., Artero, R., Lawrence, P, Maddrell, S., Baylies, M. and Skaer, H. (2003). Dual origin of the renal tubules in Drosophila: mesodermal cells integrate and polarise to establish secretory function. Curr. Biol. 13, 1052-7.
- Hazel, M.H., Ianowski, J.P., Christensen, R.J., Maddrell, S.H.P . & O'Donnell, M.J. 2003. Amino acids modulate ion transport and fluid secretionby insect Malpighian tubules. Journal of Experimental Biology. 206(1) : 79-91.
- Maddrell, S . 2004. Active transport of water by insect Malpighian tubules. Journal of Experimental Biology. 207(6) : 894-896.
- Peck, L.S. & Maddrell, S.H.P. 2005. Limitation of size by hypoxia in the fruit fly Drosophila melanogaster. Journal of Experimental Zoology Part A: Comparative Experimental Biology. 303(11): 968-975.
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