Pat Simpson's research group

Department of Zoology

Sky Lab list of publications

  • Negre and Simpson. Evolution of the achaete-scute complex in insects: convergent duplication of proneural genes. Trends Genet (2009) vol. 25 (4) pp. 147-52
  • Usui et al. Redundant mechanisms mediate bristle patterning on the Drosophila thorax. Proc Natl Acad Sci USA (2008) vol. 105 (51) pp. 20112-7
  • Simpson and Ayyar. Evolution of cis-regulatory sequences in Drosophila. Adv Genet (2008) vol. 61 pp. 67-106
  • Ayyar et al. NF-kappaB/Rel-Mediated Regulation of the Neural Fate in Drosophila. PLoS ONE (2007) vol. 2 (11) pp. e1178
  • Simpson. The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in Drosophila. Trends Genet (2007) vol. 23 (7) pp. 350-8
  • Simpson et al. Conservation of upstream regulators of scute on the notum of cyclorraphous Diptera. Dev Genes Evol (2006) vol. 216 (7-8) pp. 363-71
  • Richardson and Simpson. A conserved trans-regulatory landscape for scute expression on the notum of cyclorraphous Diptera. Dev Genes Evol (2006) vol. 216 (1) pp. 29-38
  • Marcellini and Simpson. Two or four bristles: functional evolution of an enhancer of scute in Drosophilidae. PLoS Biol (2006) vol. 4 (12) pp. e386
  • Simpson. Development and phylogeny of arthropods. Bioessays (2006) vol. 28 (2) pp. 223-4
  • Gibert et al. A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scute. Dev Biol (2005) vol. 288 (1) pp. 194-205
  • Marcellini et al. achaete, but not scute, is dispensable for the peripheral nervous system of Drosophila. Dev Biol (2005) vol. 285 (2) pp. 545-53
  • Stollewerk and Simpson. Evolution of early development of the nervous system: a comparison between arthropods. Bioessays (2005) vol. 27 (9) pp. 874-83
  • Usui-Ishihara and Simpson. Differences in sensory projections between macro- and microchaetes in Drosophilid flies. Dev Biol (2005) vol. 277 (1) pp. 170-83
  • Usui et al. Mutual exclusion of sensory bristles and tendons on the notum of dipteran flies. Curr Biol (2004) vol. 14 (12) pp. 1047-55
  • Gibert and Simpson. Evolution of cis-regulation of the proneural genes. Int J Dev Biol (2003) vol. 47 (7-8) pp. 643-51
  • Skaer et al. Transcriptional heterochrony of scute and changes in bristle pattern between two closely related species of blowfly. Dev Biol (2002) vol. 252 (1) pp. 31-45
  • Renaud and Simpson. Movement of bristle precursors contributes to the spacing pattern in Drosophila. Mech Dev (2002) vol. 119 (2) pp. 201-11
  • Simpson. Evolution of development in closely related species of flies and worms. Nat Rev Genet (2002) vol. 3 (12) pp. 907-17
  • Skaer et al. Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in Diptera. Trends Genet (2002) vol. 18 (8) pp. 399-405
  • Wülbeck and Simpson. The expression of pannier and achaete-scute homologues in a mosquito suggests an ancient role of pannier as a selector gene in the regulation of the dorsal body pattern. Development (2002) vol. 129 (16) pp. 3861-71
  • Calleja et al. How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila. Gene (2002) vol. 292 (1-2) pp. 1-12
  • Pistillo et al. scute expression in Calliphora vicina reveals an ancestral pattern of longitudinal stripes on the thorax of higher Diptera. Development (2002) vol. 129 (3) pp. 563-72
  • Wülbeck and Simpson. Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera. Development (2000) vol. 127 (7) pp. 1411-20
  • Haenlin et al. Transcriptional activity of pannier is regulated negatively by heterodimerization of the GATA DNA-binding domain with a cofactor encoded by the u-shaped gene of Drosophila. Genes Dev (1997) vol. 11 (22) pp. 3096-108
  • Cubadda et al. u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes Dev (1997) vol. 11 (22) pp. 3083-95
  • Heitzler et al. Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development (1996) vol. 122 (1) pp. 161
  • Heitzler et al. A genetic analysis of pannier, a gene necessary for viability of dorsal tissues and bristle positioning in Drosophila. Genetics (1996) vol. 143 (3) pp. 1271-86
  • Ramain et al. pannier, a negative regulator of achaete and scute in Drosophila, encodes a zinc finger protein with homology to the vertebrate transcription factor GATA-1. Development (1993) vol. 119 (4) pp. 1277-91
  • Simpson et al. Delta, notch, and shaggy: elements of a lateral signaling pathway in Drosophila. Cold Spring Harb Symp Quant Biol (1992) vol. 57 pp. 391-400

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