Dr Daniel Sobrido Camean

  • Visiting Researcher
Dr Daniel Sobrido Camean

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About

I carried out my undergraduate studies at the University of Santiago de Compostela (Spain) and received my Bachelor degree in Biology in 2013. During my Bachelor studies I attended neurobiology classes, in this subject I earned an outstanding grade. While I was in the neurobiology course I started to get more and more interested in the study of the nervous system. For example, I heard about the work of Santiago Ramón y Cajal and Eric Kandel whose reports I found very interesting. I gained a lot of interest in the field of neuroscience, therefore I decided to continue my academic training in the same university, with a Master Degree in Neuroscience, with a curriculum of Cellular and Molecular Neurobiology. For my Master´s thesis I joined the laboratory of Prof. Celina Rodicio and Dr. Antón Barreiro Iglesias. Their group was working in fish models of spinal cord injury. After a very successful Master thesis (I obtained the highest mark), I decided to stay in the same group to carry out my doctoral studies. In my PhD project, we studied molecular pathways involved in neuroprotection and axon regeneration following spinal cord injury (SCI) in lampreys.

After I have finished my PhD, I joined to the group of Dr Matthias Landgraf, who has extensive experience in the use of drosophila as a model for the study of the development of the nervous system. In the long run, I want to harness the genetics of Drosophila to identify candidate pathways and genes involved in nervous system development. Now, I have been awarded the EMBO posdoctoral fellowship to study mechanisms implicated in the critical period of the development of the nervous system.

Research

I am interested in understanding how transient experiences, during the critical period of nervous system development, lead to lasting changes of cellular properties. Critical periods are phases of nervous system development, when neuronal properties are specified and network function emerges. Their importance lies in the fact that transient disturbances during a critical period lead to lasting defects, or suboptimal nervous system function. In humans, epilepsy and several neuro-developmental psychiatric conditions are increasingly seen as caused by sub-optimal critical period experiences.

Working with the fruit fly as an experimental model system that has clearly defined critical period in late embryogenesis, I am specifically interested in two basic questions: 1. How are neuronal properties established during the critical period? 2. How are those subsequently maintained?

We find that during the critical period bio-physical aspects of the environment, such as temperature, are used as information. A few hours of being exposed to slightly cooler or warmer temperatures leads to changes in neuronal properties and animal behaviour. We think that the changes in gene expression we see might be maintained by changes in epigenetics marks. We are also investigating how those changes are initiated in the first place, looking at metabolic by-products as candidate instructive signals.

 

Key publications

Sobrido-Cameán D, Coulson B, Oswald MCW, Pettini T, Baines RA, Landgraf M. (2024), "Conserved mitochondrial reactive oxygen species and HIF1-alpha signalling during an embryonic critical period directs subsequent nervous system development". BioRxiv doi: 10.1101/2024.11.22.624842.

Sobrido-Cameán D, Oswald MCW, Bailey DMD, Mukherjee A, Landgraf M. (2023), “Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases” Frontiers in Cellular Neuroscience 16: 1106593

Sobrido-Cameán D, Robledo D, Romaus-Sanjurjo D, Perez-Cedrón C, Sánchez L, Rodicio MC, Barreiro-Iglesias A (2020), “Inhibition of gamma-secretase promotes axon regeneration after a complete spinal cord injury.” Frontiers in Cell and Developmental Biology

Sobrido-Cameán D, Fernández-López B, Pereiro N, Lafuente A, Rodicio MC, Barreiro-Iglesias A (2019), “Taurine promotes axonal regeneration after a complete spinal cord injury in lampreys” Journal of Neurotrauma

Sobrido-Cameán D, Robledo D, Sánchez L, Rodicio MC, Barreiro-Iglesias A (2019), “Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys” Disease Models and Mechanisms

Full list of publications: https://www.researchgate.net/profile/Daniel-Sobrido-Camean

Daniel Sobrido-Cameán - Web of Science Researcher Profile