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Dr Maanasa Raghavan

Dr Maanasa Raghavan

Senior Research Associate

Room 1.10 David Attenborough Building
Office Phone: 01223 (7)62935

Biography:

I am a molecular biologist, specializing in the use of next-generation sequencing (NGS) data to study human population histories. I completed my B.Sc. at the University of Toronto (2002-2006) and M.Sc. at the University of Oxford (2006-2007). My Ph.D. at the University of Copenhagen (2008-2011) and subsequent postdoctoral research at the Centre for GeoGenetics, Denmark (2012-2015) focused on resolving aspects of the early peopling of the Americas by making using of genome-scale data from ancient and modern humans from the Americas and Siberia. I am currently a Senior Research Associate at the department, Visiting Researcher at the Wellcome Trust Sanger Institute, College Research Associate at St. John's College and Gibbs Travelling Research Fellow at Newnham College.

 

Research Interests

Keywords: Population genetics, next-generation sequencing, ancient DNA/paleogenomics
My research focuses on the use of next-generation sequencing data to reconstruct human population histories and understand how and when patterns of present-day genetic diversity were formed. I use a combined approach that brings together modern and ancient DNA datasets in order to investigate human population dynamics over time and how events in the past, such as migrations and admixture, have shaped the current genetic landscape.

 

Key Publications

Seersholm F, Pedersen M, Søe M, Shokry H, Mak S, Ruter A, Raghavan M, Fitzhugh W, Kjaer K, Willerslev E, Meldgaard M, Kapel C, Hansen AJ. DNA evidence of bowhead whale exploitation by Greenlandic Paleo-Inuit 4000 years ago. Nature Communications 7: 13389. doi: 10.1038/ncomms13389 (2016)

Raghavan M*, Steinrücken M*, Harris K*, Schiffels S*, Rasmussen S*, DeGiorgio M*, Albrechtsen A*, Valdiosera C*, Ávila-Arcos MC*, Malaspinas AS*, et al. Genomic evidence for the Pleistocene and recent population history of Native Americans. Science 349(6250): aab3884 (* equal contribution) (2015)

Malaspinas AS, Lao O*, Schroeder H*, Rasmussen M*, Raghavan M*, Moltke I*, Campos PF*, Sagredo FS*, Rasmussen S*, Gonçalves VF*, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, Bernardo DV, DeGiorgio M, Duggan AT, Bastos M, Wang Y, Stenderup J, Moreno-Mayar JV, Brunak S, Sicheritz-Ponten T, Hodges E, Hannon GJ, Orlando L, Price TD, Jensen JD, Nielsen R, Heinemeier J, Olsen J, Rodrigues-Carvalho C, Lahr MM, Neves WA, Kayser M, Higham T, Stoneking M, Pena SD, Willerslev E. Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil. Current Biology 24(21): R1035-R1037 (* equal contribution) (2014)

Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G, Pagani L, Lawson DJ, Antão T, Vicente M, Mitt M, DeGiorgio M, Faltyskova Z, Xue Y, Ayub Q, Szpak M, Mägi R, Eriksson A, Manica A, Raghavan M, Rasmussen M, Rasmussen S, Willerslev E, Vidal-Puig A, Tyler-Smith C, Villems R, Nielsen R, Metspalu M, Malyarchuk B, Derenko M, Kivisild T. A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. American Journal of Human Genetics 95(5): 584-589 (2014)

Juras A, Dabert M, Kushniarevich A, Malmström H, Raghavan M, Kosicki JZ, Metspalu E, Willerslev E, Piontek J. Ancient DNA Reveals Matrilineal Continuity in Present-Day Poland over the Last Two Millennia. PLoS One 9(10): e110839 (2014)

Raghavan M, DeGiorgio M, Albrechtsen A, Moltke I, Skoglund P, Korneliussen TS, Grønnow B, Appelt M, Gulløv HC, Friesen TM, Fitzhugh W, Malmström H, Rasmussen S, Olsen J, Melchior L, Fuller BT, Fahrni SM, Stafford T Jr, Grimes V, Renouf MAP, Cybulski J, Lynnerup N, Lahr MM, Britton K, Knecht R, Arneborg J, Metspalu M, Cornejo OE, Malaspinas A-S, Wang Y, Rasmussen M, Raghavan V, Hansen TVO, Khusnutdinova E, Pierre T, Dneprovsky K, Andreasen C, Lange H, Hayes MG, Coltrain J, Spitsyn VA, Götherström, Orlando L, Kivisild T, Villems R, Crawford MH, Nielsen FC, Dissing J, Heinemeier J, Meldgaard M, Bustamante C, O’Rourke DH, Jakobsson M, Gilbert MTP, Nielsen R, Willerslev E. The genetic prehistory of the New World Arctic. Science 345(6200): 1255832 (2014)

Skoglund P, Malmström H, Omrak A, Raghavan M, Valdiosera C, Günther T, Hall P, Tambets K, Parik J, Sjögren KG, Apel J, Willerslev E, Storå J, Götherström A, Jakobsson M. Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers. Science 344(6185): 747-750 (2014)

Raghavan M*, Skoglund P*, Graf KE, Metspalu M, Albrechtsen A, Moltke I, Rasmussen S, Stafford TW Jr, Orlando L, Metspalu E, Karmin M, Tambets K, Rootsi S, Mägi R, Campos PF, Balanovska E, Balanovsky O, Khusnutdinova E, Litvinov S, Osipova LP, Fedorova SA, Voevoda MI, DeGiorgio M, Sicheritz-Ponten T, Brunak S, Demeshchenko S, Kivisild T, Villems R, Nielsen R, Jakobsson M, Willerslev E. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature 505(7481): 87-91 (* equal contribution) (2014)

Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, Malaspinas AS, Vogt J, Szklarczyk D, Kelstrup CD, Vinther J, Dolocan A, Stenderup J, Velazquez AM, Cahill J, Rasmussen M, Wang X, Min J, Zazula GD, Seguin-Orlando A, Mortensen C, Magnussen K, Thompson JF, Weinstock J, Gregersen K, Røed KH, Eisenmann V, Rubin CJ, Miller DC, Antczak DF, Bertelsen MF, Brunak S, Al-Rasheid KA, Ryder O, Andersson L, Mundy J, Krogh A, Gilbert MT, Kjær K, Sicheritz-Ponten T, Jensen LJ, Olsen JV, Hofreiter M, Nielsen R, Shapiro B, Wang J, Willerslev E. Recalibrating Eqqus evolution using the genome sequence of an early Middle Pleistocene horse. Nature 499(7456): 74-78 (2013)

Jenkins DL, Davis LG, Stafford TW Jr, Campos PF, Hockett B, Jones GT, Cummings LS, Yost C, Connolly TJ, Yohe RM 2nd, Gibbons SC, Raghavan M, Rasmussen M, Paijmans JL, Hofreiter M, Kemp BM, Barta JL, Monroe C, Gilbert MT, Willerslev E. Clovis age Western Stemmed projectile points and human coprolites at the Paisley Caves. Science 337(6091): 223-228 (2012)

Skoglund P, Malmström H, Raghavan M, Storå J, Hall P, Willerslev E, Gilbert MT, Götherström A, Jakobsson M. Origins and Genetic legacy of Neolithic farmers and hunter-gatherers in Europe. Science 336(6080): 466-469 (2012)

Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I, Metspalu M, Metspalu E, Kivisild T, Gupta R, Bertalan M, Nielsen K, Gilbert MT, Wang Y, Raghavan M, Campos PF, Kamp HM, Wilson AS, Gledhill A, Tridico S, Bunce M, Lorenzen ED, Binladen J, Guo X, Zhao J, Zhang X, Zhang H, Li Z, Chen M, Orlando L, Kristiansen K, Bak M, Tommerup N, Bendixen C, Pierre TL, Grønnow B, Meldgaard M, Andreasen C, Fedorova SA, Osipova LP, Higham TF, Ramsey CB, Hansen TV, Nielsen FC, Crawford MH, Brunak S, Sicheritz-Pontén T, Villems R, Nielsen R, Krogh A, Wang J, Willerslev E. Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature 463(7282): 757-762 (2010)

 

Other Publications

Der Sarkissian C, Allentoft ME, Avila-Arcos MC, Barnett R, Campos PF, Cappellini E, Ermini L, Fernández R, da Fonseca R, Ginolhac A, Hansen AJ, Jónsson H, Korneliussen T, Margaryan A, Martin MD, Moreno-Mayar JV, Raghavan M, Rasmussen M, Velasco MS, Schroeder H, Schubert M, Seguin-Orlando A, Wales N, Gilbert MT, Willerslev E, Orlando L. Ancient Genomics. Philosophical Transactions of the Royal Society B: Biological Sciences 370(1660): 20130387 (2015)

Schubert M, Jónsson H, Chang D, Der Sarkissian C, Ermini L, Ginolhac A, Albrechtsen A, Dupanloup I, Foucal A, Petersen B, Fumagalli M, Raghavan M, Seguin-Orlando A, Korneliussen TS, Velazquez AM, Stenderup J, Hoover CA, Rubin CJ, Alfarhan AH, Alquraishi SA, Al-Rasheid KA, MacHugh DE, Kalbfleisch T, MacLeod JN, Rubin EM, Sicheritz-Ponten T, Andersson L, Hofreiter M, Marques-Bonet T, Gilbert MT, Nielsen R, Excoffier L, Willerslev E, Shapiro B, Orlando L. Prehistoric genomes reveal the genetic foundation and cost of horse domestication. Proceedings of the National Academy of Sciences of the United States of America 111(52): E5661-5669 (2014)

Raghavan M, Espregueira Themudo G, Smith CI, Zazula G, Campos PF#. Musk ox (Ovibos moschatus) of the mammoth steppe: tracing palaeodietary and palaeoenvironmental changes over the last 50,000 years using carbon and nitrogen isotopic analysis. Quaternary Science Reviews 102: 192-201 (2014)

Fabre PH, Vilstrup JT, Raghavan M, Sarkissian CD, Willerslev E, Douzery EJ, Orlando L. Rodents of the Caribbean: origin and diversification of hutias unraveled by next-generation museomics. Biology Letters 10(7). doi: 10.1098/rsbl.2014.0266 (2014)

Vilstrup JT, Seguin-Orlando A, Stiller M, Ginolhac A, Raghavan M, Nielsen SC, Weinstock J, Froese D, Vasiliev SK, Ovodov ND, Clary J, Helgen KM, Fleischer RC, Cooper A, Shapiro B, Orlando L. Mitochondrial phylogenomics of modern and ancient equids. PLoS One 8(2): e55950 (2013)

Orlando L, Ginolhac A, Raghavan M, Vilstrup J, Rasmussen M, Magnussen K, Steinmann KE, Kapranov P, Thompson JF, Zazula G, Froese D, Moltke I, Shapiro B, Hofreiter M, Al-Rasheid KA, Gilbert MT, Willerslev E. True single-molecule DNA sequencing of a Pleistocene horse bone. Genome Research 21(10): 1705-1719 (2011)

Raghavan M, McCullagh JS, Lynnerup N, Hedges RE. Amino acid delta 13C analysis of hair proteins and bone collagen using liquid chromatography/isotope ratio mass spectrometry: paleodietary implications from intra-individual comparisons. Rapid Communications in Mass Spectrometry 24(5): 541-548 (2010)

Papageorgopoulou C, Rentsch K, Raghavan M, Hofmann MI, Colacicco G, Gallien V, Bianucci R, Rühli F. Preservation of cell structures in a medieval infant brain: a paleohistological, paleogenetic, radiological and physico-chemical study. Neuroimage 50(3): 893-901 (2010)

Suter B, Fetchko MJ, Imhof R, Graham CI, Stoffel-Studer I, Zbinden C, Raghavan M, Lopez L, Beneti L, Hort J, Fillingham J, Greenblatt JF, Giaever G, Nislow C, Stagljar I. Examining protein-protein interactions using endogenously tagged yeast arrays: the Cross-and-Capture system. Genome Research 17(12): 1774-1782 (2007)