skip to primary navigationskip to content

Dr David Burke

Dr David Burke

Senior Research Associate

Main Lecture Theatre, Austin Building
Office Phone: 01223 (3)30933

Research Themes

Evolutionary Genetics and Genomics:
All Principal Investigators:

Protein structure, computational structural biology and infectious disease

Research Interests

My research interests lie in how computational approaches can be used to understand the relationship between protein sequence, protein structure and biological function and disease. My research has focused on many aspects of computational structural bioinformatics, including both the development of new algorithms and the application of these techniques to predict the effect genetic sequence variations have on the structure, dynamics, folding and function of proteins and their involvement in the onset and proliferation of disease. I am currently applying these approaches to strain variation in the Influenza virus and other infectious diseases.

Key Publications

  • Russell CA, Fonville JM, Brown AEX, Burke DF, Smith DL, James SL, Herfst S, van Boheemen S, Linster M, Schrauwen EJ, Katzelnick L, Mosterín A, Kuiken T, Maher E, Neumann G, Osterhaus ADME, Kawaoka Y, Fouchier RAM, Smith DJ (2012) The Potential for Respiratory Droplet–Transmissible A/H5N1 Influenza Virus to Evolve in a Mammalian Host.Science 336 (6088) 1541-1547
  • Herfst S, Schrauwer EJA , Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus ADME, Fouchier RAM (2012) Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets. Science 336 (6088) 1534-1541
  • Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier RA, Pappas C, Alpuche-Aranda CM, López-Gatell H, Olivera H, López I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ. Antigenic and Genetic Characteristics of Swine-Origin (2009) A(H1N1) Influenza Viruses Circulating in Humans. Science 325(5937) :197-201

Other Publications

  • Burke DF, Worth C, Prego EM, Cheng T, Smink L, Todd J and Blundell TL (2007) Large scale bioinformatic analysis of non-synonymous SNPs. BMC Bioinformatics 8:301 doi:10.1186/1471-2105-8-301
  • Blundell TL, Sibanda BL, Montalvao RW, Brewerton S, Chelliah V, Worth C, Harmer N, Davies O and Burke DF (2006) Structural Biology and Bioinformatics in Drug Design: Opportunities and Challenges for Target identification and Lead Discovery Philosophical Transactions of the Royal Society B: Biological Sciences 361(1467):413-23
  • Bujdoso R, Burke DF and Thackray A (2005) Structural differences between allelic variants of the ovine prion protein revealed by molecular dynamics simulations Proteins: Structure, Function and Bioinformatics 61(4)
  • Burke DF and Deane CM (2001) Improved Loop prediction from sequence alone. Protein Engineering 14(7) 473-478
  • Pellegrini L, Burke DF, Mulloy B and Blundell TL (2000) The structure of the Fibroblast growth factor receptor, FGF and heparin complex. Nature 407, 1029-1034