Baylis Group
The control of animal biology by calcium signalling
Our aim is to understand the molecular signalling mechanisms that control animal development, behaviour and physiology. We place great emphasis on studying molecular mechanisms in the context of whole animal biology and in using the analysis of whole animal processes to extend our knowledge of fundamental questions at the molecular level. We achieve this by using the model organism Caenorhabditis elegans. See our Research page for more details.
Current research topics include:
- Regulation of RNAi by IP3 and calcium signalling
- Non-neuronal acetylcholine signalling
- IP3 signalling in development, physiology and behaviour
Key Publications
Nagy AI, Vázquez-Manrique RP, Lopez M, Christov C, Sequedo MD, Herzog M, Herlihy AE, Bodak M, Gatsi R and Baylis HA (2015) IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans. EMBO Rep. 16, 341-350. DOI 10.15252/embr.201439585
Baylis H A and Vazquez-Manrique R P (2011) Genetic analysis of IP3 and calcium signalling pathways in C. elegans. Biochim. Biophys. Acta-Gen. Subj. 1820, 1253-1268 DOI: 10.1016/j.bbagen.2011.11.009
Walker D S, Vazquez-Manrique R P, Gower N J D, Gregory E, Schafer W R and Baylis H A (2009) Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. PLoS Genet 5(9): e1000636. doi:10.1371/journal.pgen.1000636
Parker S P, Walker D S, Ly S and Baylis H A (2009) Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans. Mol Biol Cell 20, 1763-1771
Full list of publications via PubMed