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Department of Zoology


Research papers and reviews


Kowalski MP, Baylis HA and Krude T (2015)

Non-coding stem-bulge RNAs are required for cell proliferation and embryonic development in C. elegans.

J Cell Sci. 128: 2118-2129; doi: 10.1242/jcs.166744

Nagy AI*, Vázquez-Manrique RP*,  Lopez M,  Christov C,  Sequedo MD,  Herzog M,  Herlihy AE,  Bodak M, Gatsi R and  Baylis HA (*Joint first authors) (2015)

IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans.

EMBO Rep. 16, 341-350.  DOI 10.15252/embr.201439585

Favrin G, Bean D, Bilsland E, Boyer H, Fischer B, Russell S, Crowther D, Baylis H, Oliver S and Giannakou G (2013)

Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.

Sci Reports 3 : 3512 | DOI: 10.1038/srep0351

Baylis H A and Vazquez-Manrique R P (2011)

Genetic analysis of IP3 and calcium signalling pathways in C. elegans.

Biochim. Biophys. Acta-Gen. Subj. 1820, 1253-1268   DOI: 10.1016/j.bbagen.2011.11.009   (Invited Review)

Baylis H A and Vazquez-Manrique R P (2011)

Reverse genetic strategies in Caenorhabditis elegans: Towards controlled manipulation of the genome.

TheScientificWorldJOURNAL 11, 1394–1410. DOI 10.1100/tsw.2011.126.

Gonzalez-Cabo P, Bolinches-Amorós A, Cabello J, Ros S, Moreno S, Baylis H A, Palau F and Vazquez-Manrique R P (2011)

Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans.

J Biol Chem, 286, 21304-21314. doi: 10.1074/jbc.M110.211201

Vazquez-Manrique R P , Legg J C, Olofsson B, Ly S and Baylis H A (2009)

Improved gene targeting by homologous recombination in C. elegans using counter selection and Flp recombinase-mediated marker excision.

Genomics 95, 37-46 doi:10.1016/j.ygeno.2009.09.001

Parker S P and Baylis H A (2009)

Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.

(Article addenda) Communicative & Integrative Biology, 2 (5) 3-5.

Walker D S, Gower N J D, Gregory E, Vazquez-Manrique R P and Baylis H A (2009)

Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans.

PLoS Genet 5(9): e1000636. doi:10.1371/journal.pgen.1000636

Parker S P, Walker D S, Ly S and Baylis H A. (2009)  

Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.

Mol Biol Cell 20, 1763-1771

Vazquez-Manrique R P, Nagy A I, Legg J C, Bales O A M, Ly S and Baylis H A. (2008)

Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans.

PLoS Genet 4(3): e1000043.

Kwan C S M, Vazquez-Manrique R P, Ly S, Goyal K and Baylis H A. (2008)

TRPM channels are required for rhythmicity in the ultradian defecation rhythm of C. elegans.

BMC Phys 8:11 doi:10.1186/1472-6793-8-11

Parker S P, Peterkin H S and Baylis H A. (2007)

Muscular dystrophy associated mutations in caveolin-1 induce neurotransmission and locomotion defects in Caenorhabditis elegans.

Invert Neuro 7, 157-164.

Baylis H A and Goyal K. (2007)

TRPM channel function in C. elegans.

Biochem Soc Trans. 35, 129-132.

Vazquez-Manrique R P, Gonzalez-Cabo P, Ortiz-Martin I, Ros S, Baylis H A and Palau F. (2007)

The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.

Genomics, 89, 392-401. (Cover Article)

Asencio C, Rodríguez-Aguilera J C, Vázquez R, Baylis H, Cabello J, Schnabel R, Gavilán A and Navas P. (2006)

Differential expression pattern of coq-8 gene during development in Caenorhabditis elegans.

Gene Expr Patts 6, 433-439

Baylis H A. (2005)

Vav’s got rhythm.

Cell 123: 5-7

Vázquez-Manrique R, González-Cabo P, Ros S, Aziz H, Baylis H A and Palau F. (2005)

Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan and causes lethality in a mitochondrial complex II mutant.

FASEB J 19 (12): doi:10.1096/fj.05-4212fje (also printed Faseb J (2006) 20, 172-174)

Gower N J D, Walker D S and Baylis H A. (2005)

Inositol 1,4,5-trisphosphate signalling regulates mating and fertility in Caenorhabditis elegans males.

Mol Biol Cell 16: 3978-3986.

Culletto, E, Baylis, H A, Richmond J E, Jones A K, Fleming, J T, Squire, M D, Lewis, J A and Sattelle, D B. (2004)

The Caenorhabditis elegans unc-63 gene encodes a nicotinic acetylcholine receptor a subunit required for the function of a levamisole-sensitive receptor.

J Biol Chem 279, 42476-42483

Yin X, Gower N J D, Baylis H A, Strange K. (2004)

IP3 signaling regulates rhythmic contractile activity of myoepithelial sheath cells in C. elegans.

Mol Biol Cell 15, 3938-3949

Walker D S, Ly N S, Gower N J D and Baylis H A. (2004)

IRI-1, a LIN-15B homologue, interacts with IP3 receptors and regulates gonadogenesis, defecation and pharyngeal pumping in C. elegans.

Mol Biol Cell 15, 3073-3082

Walker, D S, Ly S, Lockwood, K and Baylis, H A. (2002)

A direct interaction between IP3 receptors and myosin II regulates IP3 signalling in Caenorhabditis elegans.

Curr Biol 12, 951-956

Walker, D S, Gower, N J D, Ly S, Bradley, G L, and Baylis, H A. (2002)

Regulated disruption of inositol 1,4,5-trisphosphate (IP3) signaling in C. elegans reveals new functions in feeding and embryogenesis.

Mol Biol Cell 13, 1329-1337

Gower, N J D, Temple, G R, Schein, J E, Marra, M, Walker, D S, and Baylis, H A. (2001)

Dissection of the promoter region of the inositol 1,4,5-trisphosphate receptor gene, itr-1, in C. elegans: A molecular basis for cell-specific expression of IP3R isoforms.

J Mol Biol, 306, 145-157

Baylis, H A, Furuichi, T, Yoshikawa, F, Mikoshiba K, Sattelle, D B. (1999)

Inositol 1,4,5-trisphosphate receptors are strongly expressed in the nervous system, pharynx, intestine, gonad and excretory cell of Caenorhabditis elegans and are encoded by a single gene (itr-1).

J Mol Biol 294, 467-476

Miguel-Aliaga, I, Culetto, E, Walker, D S, Baylis, H A, Sattelle, D B, Davies, K E. (1999)

The C. elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability.

Hum Mol Genet 8, 2133-2143

Mongan, N P, Baylis, H A, Adcock, C, Smith, G R, Sansom, M S P and Sattelle, D B. (1998)

An extensive and diverse gene family of nicotinic acetylcholine receptor a subunits in Caenorhabditis elegans.

Receptor Channel 6, 213-228

Buckingham, S D, Adcock, C, Sansom, M S P, Sattelle, D B and Baylis, H A. (1998)

Functional characterization of a mutated chicken alpha-7 nicotinic acetylcholine receptor subunit with a leucine residue inserted in transmembrane domain 2.

Br J Pharmacol 124, 747-755

Baylis, H A, Matsuda, K, Squire, M D, Fleming, J T, Harvey, R J, Darlisson, M D, Barnard, E A and Sattelle, D B. (1997)

ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit: molecular cloning and functional expression.

Receptor Channel 5, 149-158

Baylis, H A, Sattelle, D B and Lane, N J. (1996)

Genetic analysis of cholinergic nerve terminal function in invertebrates.

J Neurocyt 25, 747-762

Fleming, J T, Baylis, H A, Sattelle, D B and Lewis, J A. (1996)

Molecular biology and in vitro expression of C. elegans and parasitic nematode ionotropic receptors.

Parasitology 113, S175-S190

Squire, M D, Tornoe, C, Baylis, H A, Fleming J T, Barnard, E A. and Sattelle, D B. (1995)

Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2).

Receptor Channel 3, 107-115

 On Drosophila

Matsuda, K, Freeman, J C, Buckingham, S D, Squire, M D, Baylis, H A and Sattelle D B (1998)

Effects of the α subunit on imidacloprid sensitivity of recombinant nicotinic acetylcholine receptors.

Br J Pharmacol 123, 518-524.

Rauh, J J, Holyoke, C W, Kleier, D A, Presnail, J K, Benner, E, Cordova, D, Howard, M H, Hosie, A M, Buckingham, S D, Baylis, H A and Sattelle, D B (1997)

Polycyclic dinitriles: a novel class of potent GABAergic insecticides provides a new radioligand, [3H]BIDN.

Invert Neurosci 3, 261-268.

Matsuda, K, Hosie, A M, Buckingham S D, Squire, M D, Baylis, H A and Sattelle, D B (1996)

pH-Dependent actions of THIP and ZAPA on an ionotropic Drosophila GABA receptor.

Brain Res 739, 335-338.

Buckingham, S D, Matsuda, K, Hosie, A M, Baylis, H A, Squire, MD, Lansdell, S J, Millar, N S and Sattelle, D B (1996)

Wild-type and insecticide-resistant homo-oligomeric GABA receptors of Drosophila melanogaster stably expressed in a Drosophila cell line.

Neuropharmacology 35, 1393-1401.

Hosie, A M, Baylis, H A, Buckingham, S D, and Sattelle D B (1995)

Actions of the insecticide fipronil on dieldrin-sensitive and resistant GABA receptors of Drosophila melanogaster.

Brit J Pharmacol 115, 909-912.

Hosie, A M, Shirai, Y, Buckingham S D, Rauh, J J, Roush, R T, Baylis, H A and Sattelle D B (1995)

Blocking actions of BIDN, a bicyclic dinitrile, on wild type and dieldrin-resistant GABA (Rdl) receptors of Drosophila melanogaster expressed in Xenopus oocytes.

Brain Res 693, 257-260.

Shirai, Y, Hosie A M, Buckingham, S D, Holyoke, C W Jr, Baylis, H A and Sattelle D B (1995)

Actions of picrotoxinin analogues of an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster.

Neurosci Letts 189, 1-4.

Millar, N S, Baylis, H A, Bunting, R, Mason, W T and Sattelle, D B (1995)

Functional expression of a cloned Drosophila muscarinic acetylcholine receptor in a stable Drosophila cell line.

J Exp Biol 198, 1843-1850.


On Theleria

Baylis, H A,  Megson, A and Hall R (1995)

Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes.

Mol Biochem Parasitol 69, 211-222.

Boulter, N, Knight, P A, Hunt, P D, Hennessey, E S, Katzer, F, Tait, A, Williamson, S, Brown, D, Baylis, H A, and Hall, R (1994)

Theileria annulata sporozoite surface antigen (SPAG-1) contains neutralising determinants in the C-terminus.

Parasite Immunol 16, 97-104.

Hall, R and Baylis, H A (1993)

Tropical Theilerosis.

Parasitol Today 9, 310-312.

Baylis, H A, Allsopp, B A, Hall, R and Carrington, M (1993)

Characterisation of a glutamine and proline rich protein (QP protein) from Theileria parva.

Mol Biochem Parasitol 61, 171-178.

Allsopp, B A, Baylis, H A, Allsopp, M T E P, Cavalier-Smith, T, Bishop, R P, Carrington, D M Sohanpal, B and Spooner, P (1993)

Discrimination between six species of Theileria using oligonucleotide probes which detect small subunit rRNA sequences.

Parasitology 107, 157-165.

Baylis, H A, Megson, A, Brown, C G D, Wilkie, G F and Hall R (1992)

Theileria annulata infected cells produce abundant proteases whose activity is reduced by long term cell culture.

Parasitology 105, 417-423.

Baylis, H A, Megson, A, Mottram, J C and Hall R (1992)

Characterisation of a gene for a cysteine protease from Theileria annulata.

Mol Biochem Parasitol 54, 105-108.

Bishop, R , Sohanpal, B, Kariuki, D P, Young, A S, Nene, V, Baylis, H, Allsopp, B A, Spooner, P R, Dolan, T T and Morzaria, S P (1992)

Detection of a carrier state in Theileria parva-infected cattle using the polymerase chain reaction.

Parasitology 104, 215-232.

Megson, A, Inman, G J, Hunt, P D, Baylis, H A and Hall, R (1991)

The gene for apocytochrome B of Theileria annulata resides on a small linear extrachromosomal element.

Mol Biochem Parasitol 48, 113-116.

Baylis, H A, Sohal, S K, Carrington, M, Bishop, R P and Allsopp, B A (1991)

An unusual repetitive gene family in Theileria parva is stage-specifically transcribed.

Mol Biochem Parasitol 49, 133-142.

On Streptomyces

Strauch, E, Takano, E, Baylis, H A and Bibb, M J (1991)

The stringent response in Streptomyces coelicolor A3(2).

Mol Microbiol 5, 289-298.

Baylis, H A and Bibb, M J (1988)

Transcription analysis of the 16S rRNA gene of the rrnD gene set of Streptomyces coelicolor A3(2).

Mol Microbiol 2, 569-579.

Baylis, H A and Bibb, M J (1988)

Organisation of the ribosomal RNA genes in Streptomyces coelicolor A3(2).

Mol Gen Genet 211, 191-196.

Lawlor, E J, Baylis, H A and Chater, K F (1987)

Pleiotropic morphological and antibiotic deficiencies result from mutations in a gene encoding a tRNA-like product in Streptomyces coelicolor A3(2).

Gene Dev 1, 1305-1310.

Baylis, H A and Bibb, M J (1987)

The nucleotide sequence of a 16S rRNA gene from Streptomyces coelicolor A3(2).

Nucleic Acids Res 15, 7176.