A team at Cambridge is helping to drive biological discovery through innovation in microscope technologies

Dr Tom Worthington works on the restoration and conservation of coastal ecosystems. The data he provides sits at the heart of billion-pound initiatives to save our natural world.

Today, all non-Africans are known to have descended from a small group of people that ventured into Eurasia around 50,000 years ago. However, fossil evidence shows that there were numerous failed dispersals before this time that left no detectable traces in living people.

In a new study published today in the journal in Nature, scientists say that from around 70,000 years ago, early humans began to exploit different habitat types in Africa in ways not seen before.

At this time, our ancestors started to live in the equatorial forests of West and Central Africa, and in the Sahara and Sahel desert regions of North Africa, where they encountered a range of new environmental conditions.

As they adapted to life in these diverse habitats, early humans gained the flexibility to tackle the range of novel environmental conditions they would encounter during their expansion out of Africa.

This increase in the human niche may have been the result of social adaptations, such as long-distance social networks, which allowed for an increase in cultural exchange. The process would have been self-reinforcing: as people started to inhabit a wider proportion of the African continent, regions previously disconnected would have come into contact, leading to further exchanges and possibly even greater flexibility. The final outcome was that our species became the ultimate generalist, able to tackle a wider range of environments.

Andrea Manica, Professor of Evolutionary Ecology in the University of Cambridge’s Department of Zoology, who co-led the study with Professor Eleanor Scerri from the Max Plank Institute of Bioanthropology in Germany, said: “Around 70,000-50,000 years ago, the easiest route out of Africa would have been more challenging than during previous periods, and yet this expansion was big - and ultimately successful.”

Manica added: “It’s incredibly exciting that we were able to look back in time and pinpoint the changes that enabled our ancestors to successfully migrate out of Africa.”

Dr Emily Hallett of Loyola University Chicago, co-lead author of the study, said: “We assembled a dataset of archaeological sites and environmental information covering the last 120,000 years in Africa. We used methods developed in ecology to understand changes in human environmental niches - the habitats humans can use and thrive in - during this time.” 

Dr Michela Leonardi at the University of Cambridge and London’s Natural History Museum, the study’s other lead author, said: “Our results showed that the human niche began to expand significantly from 70,000 years ago, and that this expansion was driven by humans increasing their use of diverse habitat types, from forests to arid deserts.” 

Many explanations for the uniquely successful dispersal out of Africa have previously been made, from technological innovations, to immunities granted by interbreeding with Eurasian hominins. But there is no evidence of technological innovation, and previous interbreeding does not appear to have helped the long-term success of previous attempts to spread out of Africa.

“Unlike previous humans dispersing out of Africa, those human groups moving into Eurasia after around 60-50,000 years ago were equipped with a distinctive ecological flexibility as a result of coping with climatically challenging habitats,” said Scerri. “This likely provided a key mechanism for the adaptive success of our species beyond their African homeland.”

Previous human dispersals out of Africa - which were not successful in the long term - seem to have happened during particularly favourable windows of increased rainfall in the Saharo-Arabian desert belt, which created ‘green corridors’ for people to move into Eurasia.

The environmental flexibility developed in Africa from around 70,000 years ago ultimately resulted in modern humans’ unique ability to adapt and thrive in diverse environments, and to cope with varying environmental conditions throughout life.

This research was supported by funding from the Max Planck Society, European Research Council and Leverhulme Trust.

Adapted from a press release by the Max Planck Institute of Geoanthropology, Germany

Reference: Hallett, E. Y. et al: ‘Major expansion in the human niche preceded out of Africa dispersal.’ Nature, June 2025. DOI: 10.1038/s41586-025-09154-0.

Before the ‘Out of Africa’ migration that led our ancestors into Eurasia and beyond, human populations learned to adapt to new and challenging habitats including African forests and deserts, which was key to the long-term success of our species’ dispersal.

It’s incredibly exciting that we were able to look back in time and pinpoint the changes that enabled our ancestors to successfully migrate out of Africa.Andrea ManicaOndrej Pelanek and Martin PelanekAfrican Bush Elephant

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The successful Cambridge grantees’ work covers a range of research areas, including the development of next-generation semiconductors, new methods to identify dyslexia in young children, how diseases spread between humans and animals, and the early changes that happen in cells before breast cancer develops, with the goal of finding ways to stop the disease before it starts.

The funding, worth €721 million in total, will go to 281 leading researchers across Europe. The Advanced Grant competition is one of the most prestigious and competitive funding schemes in the EU and associated countries, including the UK. It gives senior researchers the opportunity to pursue ambitious, curiosity-driven projects that could lead to major scientific breakthroughs. Advanced Grants may be awarded up to € 2.5 million for a period of five years. The grants are part of the EU’s Horizon Europe programme. The UK agreed a deal to associate to Horizon Europe in September 2023.

This competition attracted 2,534 proposals, which were reviewed by panels of internationally renowned researchers. Over 11% of proposals were selected for funding. Estimates show that the grants will create approximately 2,700 jobs in the teams of new grantees. The new grantees will be based at universities and research centres in 23 EU Member States and associated countries, notably in the UK (56 grants), Germany (35), Italy (25), the Netherlands (24), and France (23).

“Many congratulations to our Cambridge colleagues on these prestigious ERC funding awards,” said Professor Sir John Aston, Cambridge’s Pro-Vice-Chancellor for Research. “This type of long-term funding is invaluable, allowing senior researchers the time and space to develop potential solutions for some of biggest challenges we face. We are so fortunate at Cambridge to have so many world-leading researchers across a range of disciplines, and I look forward to seeing the outcomes of their work.”

The Cambridge recipients of 2025 Advanced Grants are:

Professor Clare Bryant (Department of Veterinary Medicine) for investigating human and avian pattern recognition receptor activation of cell death pathways, and the impact on the host inflammatory response to zoonotic infections.

Professor Sir Richard Friend (Cavendish Laboratory/St John’s College) for bright high-spin molecular semiconductors.

Professor Usha Goswami (Department of Psychology/St John’s College) for a cross-language approach to the early identification of dyslexia and developmental language disorder using speech production measures with children.

Professor Regina Grafe (Faculty of History) for colonial credit and financial diversity in the Global South: Spanish America 1600-1820.

Professor Judy Hirst (MRC Mitochondrial Biology Unit/Corpus Christi College) for the energy-converting mechanism of a modular biomachine: Uniting structure and function to establish the engineering principles of respiratory complex I.

Professor Matthew Juniper (Department of Engineering/Trinity College) for adjoint-accelerated inference and optimisation methods.

Professor Walid Khaled (Department of Pharmacology/Magdalene College) for understanding precancerous changes in breast cancer for the development of therapeutic interceptions.

Professor Adrian Liston (Department of Pathology/St Catharine’s College) for dissecting the code for regulatory T cell entry into the tissues and differentiation into tissue-resident cells.

Professor Róisín Owens (Department of Chemical Engineering and Biotechnology/Newnham College) for conformal organic devices for electronic brain-gut readout and characterisation.

Professor Emma Rawlins (Department of Physiology, Development and Neuroscience/Gurdon Institute) for reprogramming lung epithelial cell lineages for regeneration.

Dr Marta Zlatic (Department of Zoology/Trinity College) for discovering the circuit and molecular basis of inter-strain and inter-species differences in learning

“These ERC grants are our commitment to making Europe the world’s hub for excellent research,” said Ekaterina Zaharieva, European Commissioner for Startups, Research, and Innovation. “By supporting projects that have the potential to redefine whole fields, we are not just investing in science but in the future prosperity and resilience of our continent. In the next competition rounds, scientists moving to Europe will receive even greater support in setting up their labs and research teams here. This is part of our “Choose Europe for Science” initiative, designed to attract and retain the world’s top scientists.”

“Much of this pioneering research will contribute to solving some of the most pressing challenges we face - social, economic and environmental,” said Professor Maria Leptin, President of the European Research Council. “Yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. We hope that more funding will be available in the future to support even more creative researchers in pursuing their scientific curiosity.”

Eleven senior researchers at the University of Cambridge have been awarded Advanced Grants from the European Research Council – the highest number of grants awarded to any institution in this latest funding round.

Westend61 via Getty ImagesScientist pipetting samples into eppendorf tube

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Research finds that appetite for bushmeat – rather than the black market for scales to use in traditional Chinese medicine – may be driving West Africa’s illegal hunting of one of the world’s most threatened mammals.

“It is with great pleasure that I welcome the latest cohort of outstanding researchers into the Fellowship of the Royal Society,” said Sir Adrian Smith, President of the Royal Society. “Their achievements represent the very best of scientific endeavour, from basic discovery to research with real-world impact across health, technology and policy. From tackling global health challenges to reimagining what AI can do for humanity, their work is a testament to the power of curiosity-driven research and innovation.

“The strength of the Fellowship lies not only in individual excellence, but in the diversity of backgrounds, perspectives and experiences each new member brings. This cohort represents the truly global nature of modern science and the importance of collaboration in driving scientific breakthroughs.”

The Fellows and Foreign Members join the ranks of Stephen Hawking, Isaac Newton, Charles Darwin, Albert Einstein, Lise Meitner, Subrahmanyan Chandrasekhar and Dorothy Hodgkin.

The new Cambridge fellows are:

Professor Edward Bullmore FMedSci FRS

Professor Ed Bullmore is Professor of Psychiatry and former Head of the Department of Psychiatry. His research mainly involves the application of brain imaging to psychiatry. He has introduced an entirely original approach to the analysis of human brain anatomy, involving graph theory and its application to small-world networks. This has had an enormous impact on the field, especially in relation to understanding the biological basis of schizophrenia and depression. His work has been key to the understanding of the 'wiring' of the human brain.

Professor Gábor Csányi FRS

Professor Gábor Csányi is Professor of Molecular Modelling in the Department of Engineering, and a Fellow of Pembroke College. His work is in the field of computational chemistry, and is focused on developing algorithms to predict the properties of materials and molecules from first principles. He pioneered the application of machine learning to molecular modelling which lead to enormous gains in the efficiency of molecular dynamics simulation.

Professor Judith Driscoll FRS

Professor Judith Driscoll is Professor of Materials Science in the Department of Materials Science and Metallurgy, and a Fellow of Trinity College. Her research is concerned with the nanoscale design and tuning of functional oxide thin film materials for energy-efficient electronic applications. A particular focus of her research group is oxide thin films, owing to their wide range of functionalities and their stability. However, their compositions tend to be complex, defects are prevalent, and interface effects play a strong role. Also, for many applications device structural dimensions are required down to nanometre length-scales. Together, all these factors produce exciting challenges for the materials scientist.

Professor Marie Edmonds FRS

Professor Marie Edmonds is Head of Department and Professor of Volcanology and Petrology in the Department of Earth Sciences. She is also a Fellow of Queens’ College. Her research focuses on understanding the impact of volcanoes on our environment and on the habitability of our planet. Her research spans the boundaries between traditional disciplines, from deciphering the nature of the interior of the Earth, to magma transport and storage in the crust, to volcano monitoring, understanding ore deposits and the dynamic chemistry of volcanic gases in the atmosphere and climate.

Professor Julian Hibberd FRS

Professor Julian Hibberd is Head of the Department of Plant Sciences and a Fellow of Emmanuel College. His research focuses on guiding optimisation of photosynthesis to improve crop yields. The C4 pathway is a complex form of photosynthesis that evolved around 30 million years ago and is now used by the most productive plants on the planet. Professor Hibberd has provided key insights into the evolution of C4 photosynthesis through analysis of plant physiology, cell specialisation, organelle development, and the control of gene expression.

Dr Gregory Jefferis FRS

Dr Gregory Jefferis is Joint Head of the Neurobiology Division at the MRC Laboratory of Molecular Biology and Director of Research of the Department of Zoology. The broad goal of his research is to understand how smell turns into behaviour in the fruit fly brain. His group is particularly interested in how odour information is processed by the higher olfactory centres that mediate innate and learned behaviour.

Professor Jason Miller FRS

Professor Jason Miller is a Professor in the Department of Pure Mathematics and Mathematical Statistics and a Fellow of Trinity College. His research interests are in probability, in particular stochastic interface models, random walk, mixing times for Markov chains, and interacting particle systems.

Professor Andrew Pitts FRS

Professor Andrew Pitts is Emeritus Professor of Theoretical Computer Science in the Department of Computer Science and Technology and an Emeritus Fellow of Darwin College. His research makes use of techniques from category theory, mathematical logic and type theory to advance the foundations of programming language semantics and theorem proving systems. His aim is to develop mathematical models and methods that aid language design and the development of formal logics for specifying and reasoning about programs. He is particularly interested in higher-order typed programming languages and in dependently typed logics.

Dr Marta Zlatic FRS

Dr Marta Zlatic is Programme Leader at the MRC Laboratory of Molecular Biology, and Director of Research in the Department of Zoology. She is also a Fellow of Trinity College. Her research aims to understand the relationship between the structure of the nervous system and its function and to discover the basic principles by which neural circuits implement fundamental computations. A major focus of her research is the circuit implementation of learning and decision-making.

Nine outstanding Cambridge scientists have been elected as Fellows of the Royal Society, the UK’s national academy of sciences and the oldest science academy in continuous existence.

Tom MorrisEntrance to the Royal Society

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Researchers at Cambridge are leading conversations to make sure we embrace AI with eyes wide open.

The metals have previously been shown to damage the health of pollinators, which ingest them in nectar as they feed, leading to reduced population sizes and death. Even low nectar metal levels can have long-term effects, by affecting bees’ learning and memory - which impacts their foraging ability.

Researchers have found that common plants including white clover and bindweed, which are vital forage for pollinators in cities, can accumulate arsenic, cadmium, chromium and lead from contaminated soils.

Metal contamination is an issue in the soils of cities worldwide, with the level of contamination usually increasing with the age of a city. The metals come from a huge range of sources including cement dust and mining.

The researchers say soils in cities should be tested for metals before sowing wildflowers and if necessary, polluted areas should be cleaned up before new wildflower habitats are established.

The study highlights the importance of growing the right species of wildflowers to suit the soil conditions. 

Reducing the risk of metal exposure is critical for the success of urban pollinator conservation schemes. The researchers say it is important to manage wildflower species that self-seed on contaminated urban land, for example by frequent mowing to limit flowering - which reduces the transfer of metals from the soil to the bees.

The results are published today in the journal Ecology and Evolution. 

Dr Sarah Scott in the University of Cambridge’s Department of Zoology and first author of the report, said: “It’s really important to have wildflowers as a food source for the bees, and our results should not discourage people from planting wildflowers in towns and cities.

“We hope this study will raise awareness that soil health is also important for bee health. Before planting wildflowers in urban areas to attract bees and other pollinators, it’s important to consider the history of the land and what might be in the soil – and if necessary find out whether there’s a local soil testing and cleanup service available first.”

The study was carried out in the post-industrial US city of Cleveland, Ohio, which has over 33,700 vacant lots left as people have moved away from the area. In the past, iron and steel production, oil refining and car manufacturing went on there. But any land that was previously the site of human activity may be contaminated with traces of metals.

To get their results, the researchers extracted nectar from a range of self-seeded flowering plants that commonly attract pollinating insects, found growing on disused land across the city. They tested this for the presence of arsenic, cadmium, chromium and lead. Lead was consistently found at the highest concentrations, reflecting the state of the soils in the city.

The researchers found that different species of plant accumulate different amounts, and types, of the metals. Overall, the bright blue-flowered chicory plant (Cichorium intybus) accumulated the largest total metal concentration, followed by white clover (Trifolium repens), wild carrot (Daucus carota) and bindweed (Convolvulus arvensis). These plants are all vital forage for pollinators in cities - including cities in the UK - providing a consistent supply of nectar across locations and seasons.

There is growing evidence that wild pollinator populations have dropped by over 50% in the last 50 years, caused primarily by changes in land use and management across the globe. Climate change and pesticide use also play a role; overall the primary cause of decline is the loss of flower-rich habitat.

Pollinators play a vital role in food production: many plants, including apple and tomato, require pollination in order to develop fruit. Natural ‘pollination services’ are estimated to add billions of dollars to global crop productivity. 

Scott said: “Climate change feels so overwhelming, but simply planting flowers in certain areas can help towards conserving pollinators, which is a realistic way for people to make a positive impact on the environment.”

The research was funded primarily by the USDA National Institute of Food and Agriculture.

Reference 
Scott, S.B.& Gardiner, M.M.: ‘Trace metals in nectar of important urban pollinator forage plants: A direct exposure risk to pollinators and nectar-feeding animals in cities.’ Ecology and Evolution, April 2025.  DOI: 10.1002/ece3.71238
 

Wildflowers growing on land previously used for buildings and factories can accumulate lead, arsenic and other metal contaminants from the soil, which are consumed by pollinators as they feed, a new study has found.

Our results should not discourage people from planting wildflowers in towns and cities. But.. it’s important to consider the history of the land and what might be in the soil."Sarah ScottSarah ScottChicory growing in a vacant lot

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UCAS evaluation shows the most engaged sixth formers saw their results jump by a grade on average, were up to four times as successful in achieving an A*, and around twice as successful in securing an Oxbridge place.

Rebalancing the planet must happen faster. Cambridge researchers are using AI to help.