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Department of Zoology

 

Biography

I carried out my undergraduate studies at the University of Santiago de Compostela (Spain) and received my Bachelor degree in Biology in 2013. During my Bachelor studies I attended neurobiology classes, in this subject I earned an outstanding grade. While I was in the neurobiology course I started to get more and more interested in the study of the nervous system. For example, I heard about the work of Santiago Ramón y Cajal and Eric Kandel whose reports I found very interesting. I gained a lot of interest in the field of neuroscience, therefore I decided to continue my academic training in the same university, with a Master Degree in Neuroscience, with a curriculum of Cellular and Molecular Neurobiology. For my Master´s thesis I joined the laboratory of Prof. Celina Rodicio and Dr. Antón Barreiro Iglesias. Their group was working in fish models of spinal cord injury. After a very successful Master thesis (I obtained the highest mark), I decided to stay in the same group to carry out my doctoral studies. In my PhD project, we studied molecular pathways involved in neuroprotection and axon regeneration following spinal cord injury (SCI) in lampreys.

After I have finished my PhD, I joined to the group of Dr Matthias Landgraf, who has extensive experience in the use of drosophila as a model for the study of the development of the nervous system. In the long run, I want to harness the genetics of Drosophila to identify candidate pathways and genes involved in nervous system development. Now, I have been awarded the EMBO posdoctoral fellowship to study mechanisms implicated in the critical period of the development of the nervous system.

Research

I am interested in understanding how transient experiences, during the critical period of nervous system development, lead to lasting changes of cellular properties. Critical periods are phases of nervous system development, when neuronal properties are specified and network function emerges. Their importance lies in the fact that transient disturbances during a critical period lead to lasting defects, or suboptimal nervous system function. In humans, epilepsy and several neuro-developmental psychiatric conditions are increasingly seen as caused by sub-optimal critical period experiences.

Working with the fruit fly as an experimental model system that has clearly defined critical period in late embryogenesis, I am specifically interested in two basic questions: 1. How are neuronal properties established during the critical period? 2. How are those subsequently maintained?

We find that during the critical period bio-physical aspects of the environment, such as temperature, are used as information. A few hours of being exposed to slightly cooler or warmer temperatures leads to changes in neuronal properties and animal behaviour. We think that the changes in gene expression we see might be maintained by changes in epigenetics marks. We are also investigating how those changes are initiated in the first place, looking at metabolic by-products as candidate instructive signals.

Publications

Key publications: 

Sobrido-Cameán D, Robledo D, Romaus-Sanjurjo D, Perez-Cedrón C, Sánchez L, Rodicio MC, Barreiro-Iglesias A (2020), “Inhibition of gamma-secretase promotes axon regeneration after a complete spinal cord injury.” Frontiers in Cell and Developmental Biology

Sobrido-Cameán D, Fernández-López B, Pereiro N, Lafuente A, Rodicio MC, Barreiro-Iglesias A (2019), “Taurine promotes axonal regeneration after a complete spinal cord injury in lampreys” Journal of Neurotrauma

Sobrido-Cameán D, Robledo D, Sánchez L, Rodicio MC, Barreiro-Iglesias A (2019), “Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys” Disease Models and Mechanisms

Other publications: 

Sobrido-Cameán D, Barreiro-Iglesias A (2022), “Neural Morpholino studies shed light on the signalling pathways regulating axon regeneration in lampreys” Neural regeneration research 17(7): 1475–1477

Sobrido-Cameán D, Anadón R, Barreiro-Iglesias A (2021), “Expression of urocortin 3 mRNA in the central nervous system of the sea lamprey Petromyzon marinus” Biology 10: 978

Sobrido-Cameán D, Yañez-Guerra LA, Deber A, Rodicio MC, Barreiro-Iglesias (2021), “Expression of kisspeptin 1 in the brain of the adult sea lamprey Petromyzon marinus” Life 11: 1174

Quelle-Regaldie A, Sobrido-Cameán D, Barreiro-Iglesias A, Sobrido MJ, Sánchez L (2021), “Zebrafish models of Autosomal Dominant Ataxias” Cells 10, 421

Quelle-Regaldie A, Sobrido-Cameán D, Barreiro-Iglesias A, Sobrido MJ, Sánchez L (2021), “Zebrafish models of Autosomal Recessive and X-linked Hereditary Ataxias” Cells 10, 836

Sobrido-Cameán D, Yáñez-Guerra L, Deber A, Freire-Delgado M, Cacheiro-Vázquez R, Rodicio MC, Tostivint H, Anadón R, Barreiro-Iglesias A (2021), “Differential expression of three somatostatin genes in the central nervous system of the sea lamprey” Brain Structure and Function

Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M (2020), “Developmentally-programmed cellular senescence is conserved and widespread in zebrafish” Aging

Sobrido-Cameán D, Tostivint H, Mazan S, Rodicio MC, Rodríguez-Moldes I, Candal E, Anadón R, Barreiro-Iglesias A (2020), “In situ hybridization study of the differential expression of five prosomatostatin genes in the central nervous system of the catshark Scyliorhinus canicula” Journal of Comparative Neurology

Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M (2019), “Cell senescence contributes to tissue regeneration in Zebrafish” Aging Cell

Sobrido-Cameán D, Yáñez-Guerra LA, Robledo D, López-Varela E, Rodicio MC, Elphick MR, Anadón R, Barreiro-Iglesias A (2019), “Cholecystokinin in the central nervous system of the sea lamprey Petromyzon marinus: precursor identification and neuroanatomical relationships with other neuronal signalling systems” Brain Structure and Function

Sobrido-Cameán D, Yáñez-Guerra LA, Lamanna F, Conde-Fernández C, Kaessmann H, Elphick MR, Anadón R, Rodicio MC, Barreiro-Iglesias A (2019), “Galanin in an agnathan: precursor identification and localisation of expression in the brain of the sea lamprey Petromyzon marinus” Frontiers in Neuroanatomy

Sobrido-Cameán D, Barreiro-Iglesias A (2018), “Role of caspase-8 and Fas in cell death after spinal cord injury” Frontiers in Molecular Neuroscience

Sobrido-Cameán D, Rodicio MC, Barreiro-Iglesias A (2018), “The role of serotonin in nervous system regeneration: lessons from regenerating animal models” Neural Regeneration Research

Sobrido-Cameán D, Rodicio MC, Barreiro-Iglesias A (2018), “Data on the effect of a muscimol treatment in caspase activation in descending neurons of lampreys after a complete spinal cord injury” Data in Brief

Barreiro-Iglesias A, Fernández-López B, Sobrido-Cameán D, Anadón R (2017), “ Organization of AlphaTransducin Immunoreactive System in the Brain and Retina of Larval and Young Adult Sea Lamprey (Petromyzon marinus), and their Relationship with Other Neural Systems” Journal of Comparative Neurology

Barreiro-Iglesias A, Sobrido-Cameán D, Shifman MI (2017), “Retrograde activation of the extrinsic apoptotic pathway in spinal-projecting neurons after a complete spinal cord injury in lampreys” BioMed Research International

Fernández-López B, Sobrido-Cameán D, Anadón R, Rodicio MC, Barreiro-Iglesias A (2017), “Restricted co-localization of glutamate and dopamine in neurons of the adult sea lamprey brain” Journal of Anatomy

Romaus-Sanjurjo, D, Fernández-López, B, Sobrido-Cameán, D, Barreiro-Iglesias, A, Rodicio, MC (2017), “Cloning of the gabaB Receptor Subunits B1 and B2 and their Expression in the Central Nervous System of the Adult Sea Lamprey” Frontiers in Neuroanatomy