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Department of Zoology

 

https://www.WeilLabCambridge.com/

Our work aims to address the fundamental, and fascinating, question of how a single cell becomes a fully functioning organism. We want to understand the mechanisms that underpin the spatial and temporal coordination of egg and early embryo development. We have a particular interest in the role of biomolecular condensates in the regulation of mRNAs at these stages. 

Biography

I am an energetic, collaborative, and hands-on supervisor. I believe in supporting the personal growth, independence, and skill set development (technical, academic, and social) of group members so they are successful in any career.

  • 2013-present: Group Leader, Associate Professor; Department of Zoology, University of Cambridge. 
  • 2010-2013: Junior Research Fellowship; Three year post as a member of the Senior Common Room at Worcester College, University of Oxford.
  • 2008-2010: Marie Curie Incoming International Fellowship; Fellowship for postdoctoral research at the University of Oxford.
  • 2002-2008: Princeton University; Doctor of Philosophy, Department of Molecular Biology, Advisor: Prof. Elizabeth R. Gavis.
  • 1998-2002: Washington University in St. Louis; Bachelor of Science, Major: Biology, Minors: Drama, Legal Studies, Pre Medical Studies. 

Research

Regulating protein expression is fundamental to the life of any cell. One way this can be done is through mRNA association with biomolecular condensates, membrane-less compartments that function as reaction crucibles and sub-cellular organisational hubs. Condensates have been shown to be involved in effectively all aspects of biology, including development, neurobiology, and pathogenesis, and are a promising target for new therapeutic innovation. However, to inform future drug discovery, an in vivo molecular understanding of condensates is required. 

In early animal development, condensates are important in the patterning of embryonic axes, formation of neuronal networks, and movement of cells. We test the formation and function of a conserved biomolecular condensate, processing bodies (P Bodies), in Drosophila exploiting their advantages for sophisticated genetics and live imaging.  Research in fruit flies has identified thousands of genes with human homologues and has provided key insights into developmental pathways, oncology, neurobiology and immunology. 

Our use of the egg chamber and early embryo has the experimental benefits of being an in vivo developing system, allowing for a controllable switch at egg activation, ease of physical manipulation, and providing ample material for experimentation. Recently, we have shown that P bodies in the mature Drosophila egg are primarily regulated by structurally distinct proteins and weak multivalent interactions. In vivo, P body integrity is controlled through an arrested physical state which is critical for the storage of mRNAs. 

Overall, we aim to fully elucidate the formation, maintenance and dynamics of P bodies and how these condensates control mRNA metabolism. This work will shed light on the fundamental mechanisms controlling cellular protein production and inform medical advancements.

Publications

Key publications: 

RECENT PAPERS:

* Sankaranarayanan M., Emenecker R.J., Wilby E.L.,  Jahnel M., Trussina  I.R.E., Wayland M., Alberti S., Holehouse A.S., Weil T.T. (2021) The arrested state of processing bodies supports mRNA regulation in early development. Dev Cell. Accepted September. 

* York-Andersen A.H., Wood B.W., Wilby E.L., Berry A.S., Weil T.T. (2021) Osmolarity-regulated swelling initiates egg activation in Drosophila. Open Biol. 11: 210067. https://doi.org/10.1098/rsob.210067

* Sankaranarayanan M., and Weil T.T. (2020). Granule regulation by phase separation during Drosophila oogenesis. Emerg Top Life Sci., 4(3):343-352. doi: 10.1042/ETLS20190155.

* York-Andersen A.H., Hu Q., Wood B.W., Wolfner M.F., and Weil T.T. (2020) A calcium-mediated actin redistribution at egg activation in Drosophila. Mol Reprod Dev., 87(2):293-304. doi: 10.1002/mrd.23311. 

***ALL PAPERS: https://pubmed.ncbi.nlm.nih.gov/?term=Weil+TT&cauthor_id=31880382

Supervisions

Research supervision: 

I have three PhD  and Masters Projects available in 2022-23. For more information please visit: www.WeilLabCambridge.com 

I will also consider applicants for bespoke PhD projects and MPhils. Please email me to set up a discussion. 

Deputy Head of School - Undergraduate Strategy
Associate Professor

Contact Details

Room B31
01223(7)65391
Accepting applications for PhD students.
Available for consultancy

Affiliations