Research Associate
Project Team Leader for the Drosophila Connectomics group
Department of Zoology
Downing Street
Cambridge, CB2 3EJ UK
Websites:
Biography:
The Wellcome Trust has made a £3.25M award to the Department of Zoology to support Drosophila connectomics. This will be delivered in collaboration with co-applicants from HHMI Janelia Research Campus in the US, the MRC LMB in Cambridge and the University of Oxford Centre for Neural Circuits and Behaviour. The project aims to reconstruct neurons and their connections from a recently completed whole brain electron microscopy volume of the adult fly brain obtained at Janelia. The goal is to obtain a comprehensive understanding of the neural circuits basis of memory storage and retrieval. Zoology will host about 8 team members who will carry out computer-assisted neuronal reconstruction and data analysis. They will interact closely with a similar team in the US as well as experimental groups in Oxford and Cambridge.
Research Group
- Drosophila Connectomics:
- Project Team Leader
Keywords
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Key Publications
Costa, M., A.D., Manton, Ostrovsky, J.D., Prohaska, S. and Jefferis, G.S.X.E. (2016).NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases. Neuron, 91(2), 293-311
Costa, M., A.D., Manton, Ostrovsky, J.D., Prohaska, S. and Jefferis, G.S.X.E. (2014).NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases. Bioarxiv
Manton, J.D., Ostrovsky, A.D., Goetz, L., Costa, M., Rohlfing, T., and Jefferis, G.S.X.E. (2014).Combining genome-scale Drosophila 3D neuroanatomical data by bridging template brains. Bioarxiv
Araya, C., Tawk, M., Girdler, G. C., Costa, M., Carmona-Fontaine, C. and Clarke, J. D. (2014).Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo. Neural Dev. 9, 9.
Costa, M., Calleja, M., Alonso, C. R. and Simpson, P. (2013). The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera.Dev. Biol. 1–11.
Costa M., Reeve S., Grumbling G., Osumi-Sutherland D. (2013). The Drosophila anatomy ontology. Journal of Biomedical Semantics 4 (32).
Correia, C. (1), Costa, M. (1), Moraes, F. (1), Bom J., Nóvoa A. and Mallo, M. (2007). Bmp2 is required for migration but not for induction of neural crest cells in the mouse. Developmental Dynamics 236, 2493-2501. (1) equal contributors.