skip to primary navigationskip to content
 

Dr Marta Costa

Dr Marta Costa

Senior Research Associate

Project Team Leader for the Drosophila Connectomics group

Room 316, Austin Building
Department of Zoology
Downing Street
Cambridge, CB2 3EJ UK

Office Phone: 01223 (3)34455

Biography:

I am the Project Team Leader for the Drosophila  Connectomics group, started in October 2016, aims to build the adult olfactory connectome of Drosophila. That is, to describe every neuron that is involved in olfactory behaviour, and its connections. We are part of a consortium of groups in Cambridge (Jefferis, Landgraf), Oxford (Waddell) and Janelia Research Campus (Rubin, Bock labs) that are doing this, using a whole brain EM volume generated at Janelia by Davi Bock's group.
The project focuses on the pathways and neuropils involved in innate and learned olfactory behaviour, from the primary olfactory centre - the antennal lobe - to the integration centres - lateral horn (LH) for innate and mushroom body (MB) for learned behaviours. Within the MB, we wish to describe the modulation of dopaminergic neurons (convey valence), onto the Kenyon cells-MB output neurons synapses, the site of likely synaptic plasticity. For the LH, we wish to understand if there is integration of odours of similar valence, and how this integration is achieved.

I have also been a part of the Virtual Fly Brain project - the neuroinformatic hub for Drosophila neuroscience information - since 2011, working on data curation and image analysis.

Research Group

Drosophila Connectomics:
Project Team Leader

Keywords

  • Neuroanatomy
  • Image Visualisation
  • Electon Microscopy
  • Cellular and Molecular Neuroscience
  • computational neuroanatomy
  • Imaging technologies

Key Publications

Costa, M., A.D., Manton, Ostrovsky, J.D., Prohaska, S. and Jefferis, G.S.X.E. (2016).NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases. Neuron, 91(2), 293-311

Costa, M., A.D., Manton, Ostrovsky, J.D., Prohaska, S. and Jefferis, G.S.X.E. (2014).NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases. Bioarxiv
Manton, J.D., Ostrovsky, A.D., Goetz, L., Costa, M., Rohlfing, T., and Jefferis, G.S.X.E. (2014).Combining genome-scale Drosophila 3D neuroanatomical data by bridging template brains. Bioarxiv

Araya, C., Tawk, M., Girdler, G. C., Costa, M., Carmona-Fontaine, C. and Clarke, J. D. (2014).Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo. Neural Dev. 9, 9.

Costa, M., Calleja, M., Alonso, C. R. and Simpson, P. (2013). The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera.Dev. Biol. 1–11.

Costa M., Reeve S., Grumbling G., Osumi-Sutherland D. (2013). The Drosophila anatomy ontology. Journal of Biomedical Semantics 4 (32).

Correia, C. (1), Costa, M. (1), Moraes, F. (1), Bom J., Nóvoa A. and Mallo, M. (2007). Bmp2 is required for migration but not for induction of neural crest cells in the mouse. Developmental Dynamics 236, 2493-2501. (1) equal contributors.