Biography
I am the Project Team Leader for the Drosophila Connectomics group, started in October 2016 and funded by the Wellcome Trust. The project aims to build the adult olfactory connectome of Drosophila, that is, to describe the neurons involved in innate and learned olfactory behaviour, and its connections to other neurons.
We are part of a consortium of groups in Cambridge (Jefferis, Landgraf), Oxford (Waddell) and Janelia Research Campus (Rubin, Bock) that are doing this, using a whole brain EM volume generated at Janelia by Davi Bock's group (Zheng et al., 2018). For more detail on our research, see our group page.
I have also been a part of the Virtual Fly Brain project - the neuroinformatic hub for Drosophila neuroscience information - since 2011, working on data curation and image analysis, and now as a Co-Investigator.
Publications
Key publications:
- Paavo Huoviala, Michael-John Dolan*, Fiona M. Love*, Shahar Frechter, Ruairí J.V. Roberts, Zane Mitrevica, Philipp Schlegel, Alexander Shakeel Bates, Yoshinori Aso, Tiago Rodrigues, Hannah Cornwall, Marcus Stensmyr, Davi Bock, Gerald M. Rubin, Marta Costa, Gregory S.X.E. Jefferis (2018) Neural circuit basis of aversive odour processing in Drosophila from sensory input to descending output, bioRxiv
- P Schlegel (1), M Costa (1), GSXE Jefferis (2017) Learning from Connectomics on the fly, Current Opinion in Insect Science, 24:96–105
- E Marin & M Costa (2017) Sensory Neurobiology: Wet Fly Fishing, Current Biology, 27:R833–R852
- Costa, M., A.D., Manton, Ostrovsky, J.D., Prohaska, S. and Jefferis, G.S.X.E. (2016).NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases. Neuron, 91(2), 293-311
- Manton, J.D., Ostrovsky, A.D., Goetz, L., Costa, M., Rohlfing, T., and Jefferis, G.S.X.E. (2014).Combining genome-scale Drosophila 3D neuroanatomical data by bridging template brains. bioRxiv
- Costa, M., Calleja, M., Alonso, C. R. and Simpson, P. (2013). The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera. Dev. Biol. 1–11.
- Costa M., Reeve S., Grumbling G., Osumi-Sutherland D. (2013). The Drosophila anatomy ontology. Journal of Biomedical Semantics 4 (32).
Other publications:
- Michael-John Dolan, Shahar Frechter, Alexander Shakeel Bates, Chuntao Dan, Paavo Huoviala, Ruairi J.V. Roberts, Philipp Schlegel, Serene Dhawan, Remy Tabano, Heather Dionne, Christina Christoforou, Kari Close, Ben Sutcliffe, Bianca Giuliani, Feng Li, Marta Costa, Gudrun Ihrke, Geoffrey Meissner, Davi Bock, Yoshinori Aso, Gerald Rubin, Gregory Jefferis (accepted). "Neurogenetic dissection of the Drosophila lateral horn reveals output, functions and interaction with the mushroom body", eLife
- Johannes Felsenberg, Pedro F. Jacob, Thomas Walker, Oliver Barnstedt, Amelia J. Edmondson-Stait, Markus W. Pleijzier, Nils Otto, Philipp Schlegel, Nadiya Sharifi, Emmanuel Perisse, Carlas S. Smith, J. Scott Lauritzen, Marta Costa, Gregory S.X.E. Jefferis, Davi D. Bock and Scott Waddell (2018) Integration of Parallel Opposing Memories Underlies Memory Extinction. Cell
- R. C. Court, J. D. Armstrong, J. Borner, G. Card, M. Costa, M. Dickinson, C. Duch, W. Korff, R. Mann, D. Merritt, R. Murphey, et al. (2017). A Systematic Nomenclature for the Drosophila Ventral Nervous System. bioRxiv
- S. J. Marygold, G. Antonazzo, H. Attrill, M. Costa, M. A. Crosby, G. dos Santos, J. L. Goodman, L. S. Gramates, B. B. Matthews, A. J. Rey, et al. (2016). Exploring FlyBase Data Using QuickSearch. Current Protocols in Bioinformatics, 1–31.
- Costa, M., A.D., Manton, Ostrovsky, J.D., Prohaska, S. and Jefferis, G.S.X.E. (2014).NBLAST: Rapid, sensitive comparison of neuronal structure and construction of neuron family databases. bioRxiv
- Araya, C., Tawk, M., Girdler, G. C., Costa, M., Carmona-Fontaine, C. and Clarke, J. D. (2014).Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo. Neural Dev. 9, 9.
- Correia, C. (1), Costa, M. (1), Moraes, F. (1), Bom J., Nóvoa A. and Mallo, M. (2007). Bmp2 is required for migration but not for induction of neural crest cells in the mouse. Developmental Dynamics 236, 2493-2501. (1) equal contributors.
