Our aim is to understand the molecular signalling mechanisms that control animal development, behaviour and physiology. We place great emphasis on studying molecular mechanisms in the context of whole animal biology and in using the analysis of whole animal processes to extend our knowledge of fundamental questions at the molecular level. We achieve this by using the model organism Caenorhabditis elegans. 

We also work on using C. elegans to model human disease.

Current research topics include:

• Regulation of RNAi by IP3 and calcium signalling

• Non-neuronal acetylcholine signalling

• IP3 signalling in development, physiology and behaviour

Key Publications

Nagy AI, Vázquez-Manrique RP,  Lopez M,  Christov C,  Sequedo MD,  Herzog M,  Herlihy AE,  Bodak M, Gatsi R and  Baylis HA  (2015) IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans. EMBO Rep. 16, 341-350.  DOI 10.15252/embr.201439585

Baylis H A and Vazquez-Manrique R P (2011) Genetic analysis of IP3 and calcium signalling pathways in C. elegans. Biochim. Biophys. Acta-Gen. Subj. 1820, 1253-1268   DOI: 10.1016/j.bbagen.2011.11.009 

Walker D S, Vazquez-Manrique R P, Gower N J D, Gregory E, Schafer W R and Baylis H A (2009)  Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. PLoS Genet 5(9): e1000636. doi:10.1371/journal.pgen.1000636

Parker S P, Walker D S, Ly S and Baylis H A (2009)  Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans. Mol Biol Cell 20, 1763-1771

Full list of publications via PubMed